Overview: Researchers at the University of Maryland have discovered the signaling molecule, called cyclic-di-GMP, which activates biofilm formation. The most virulent classification of bacteria falls into the Gram-negative group and they are all known as biofilm producers. Members of this group include: Helicobacter pylori, E. coli, Neisseria gonorrhoeae, Haemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa and many others. Biofilm is a protective coating or shield; made-up of sugars, DNA and protein; that enables these bacteria to evade detection and makes them almost impossible to kill.
Very soon we will have a proven way to disrupt these bacteria created force-fields and break them it down. Either through bioengineering other bacteria or synthesising enzymes which can be administered directly to a wound or through pharmaceutical administration. Until this day, we still have our hands tied when it comes to easily or successfully treating infections caused by gram-negative bacteria.
Original Article: ‘Off switch’ enzyme in biofilms identified to prevent formation